Treatment response is the degree of improvement associated with a treatment over an appropriate period. It can be measured through symptoms, distress, functioning and the person’s own priorities. A partial response may still be valuable…Continue Reading
Safety monitoring checks for adverse effects and changes in physical health during antipsychotic treatment. Depending on the medicine and circumstances, this can include weight, blood pressure, glucose, lipids, movement symptoms and hormonal concerns. An electrocardiogram…Continue Reading
Antipsychotics can reduce the intensity, frequency or impact of hallucinations, delusions and disorganised thinking. Improvement may involve feeling less threatened or less compelled to act on an experience before its content fully changes. Some medicines…Continue Reading
Most established antipsychotics reduce D2-mediated dopamine signalling through antagonism or partial agonism. Many also affect serotonin, histamine, adrenergic or muscarinic receptors. These additional actions help explain differences in sedation, appetite, blood pressure and other effects…Continue Reading
Dose is the amount of medicine administered, while receptor occupancy is the proportion of a receptor population engaged at a particular exposure. They are related but not equivalent. Absorption, metabolism, interactions and active metabolites influence…Continue Reading