Treatment-resistant schizophrenia generally involves significant symptoms that persist after at least two adequate antipsychotic trials. Exact definitions differ, and adequate means more than having received a prescription. The medicine must have been used at an…Continue Reading
An adequate medication trial requires a suitable medicine, appropriate dose or exposure, sufficient duration and a meaningful assessment of response. The details depend on the drug and clinical situation. Time spent at a very low…Continue Reading
Apparent resistance occurs when symptoms seem unresponsive but another explanation limits the treatment trial. Possibilities include inconsistent access, missed doses, interactions, rapid metabolism, ongoing substance effects or a diagnosis that needs revision. A medicine may…Continue Reading
Clozapine is a principal evidence-based option for appropriately identified treatment-resistant schizophrenia. Its consideration follows review of previous trials, persistent symptoms, physical health and monitoring requirements. The decision should include the person’s preferences and a realistic…Continue Reading
Persistent symptoms are difficulties that continue despite improvement or treatment. They may involve psychosis, negative symptoms, cognition, mood or anxiety. Their persistence does not identify one cause, and each domain needs assessment. A voice that…Continue Reading