Serotonin signalling occurs when serotonin is released and binds to receptors on nearby cells. Its effects are regulated by synthesis, release, reuptake and metabolism. Different receptors trigger different cellular responses, so changing serotonin signalling in…Continue Reading
Serotonin receptors are grouped into families identified as 5-HT1 through 5-HT7, with several subtypes. Most are G protein-coupled receptors; 5-HT3 is an ion channel. They differ in distribution, signalling and function. A drug’s action at…Continue Reading
5-HT2A receptors are important targets of many second-generation antipsychotics. Blocking them can alter interactions between serotonin and dopamine pathways. This has been proposed as one contributor to the lower movement-related risk of some receptor profiles…Continue Reading
5-HT1A receptors occur in several brain systems, including as autoreceptors that influence serotonin neuron activity. Some antipsychotics, such as aripiprazole, cariprazine and lurasidone, have partial agonist activity at this receptor. Researchers investigate possible contributions to…Continue Reading
Serotonin and dopamine systems influence one another through networks rather than operating independently. Activity at particular serotonin receptors can change dopamine release or the behaviour of circuits receiving dopamine. This is relevant to antipsychotics that…Continue Reading