Sedation can reduce participation even when psychotic symptoms improve. Someone may struggle to wake for appointments, maintain attention at work or take part in family life. Slower reactions can affect safety, while visible inactivity may…Continue Reading

Histamine contributes to wakefulness through H1 receptors in the brain. Blocking these receptors can produce sleepiness, which helps explain the sedating properties of several antipsychotics. The same broad receptor system is also relevant to appetite…Continue Reading

Daytime sleepiness is a tendency to become drowsy or fall asleep during waking hours. It can interfere with reading, conversation, study and work. Antipsychotic effects are one possible cause, but insufficient sleep, sleep apnoea, irregular…Continue Reading

Sedation can vary with dose, blood concentration and the time since a medicine was taken. Formulation and half-life also influence the pattern. A medication taken in the evening may still affect alertness the next day…Continue Reading