In schizophrenia, relapse usually refers to a clinically meaningful increase in psychotic symptoms or related impairment following improvement. It may involve returning voices, stronger delusional conviction or greater disorganisation. Some research definitions use symptom scores…Continue Reading

Assessment after a first psychotic episode explores symptoms, onset, functioning and possible causes. It includes a mental state examination, physical health review and discussion of substances and medicines. The person’s description is central, while previous…Continue Reading

The causes of a first psychotic presentation include psychiatric, substance-related and medical conditions. Schizophrenia is one possibility, but mania, severe depression and schizoaffective disorder may also involve psychosis. Intoxication, withdrawal and some prescribed medicines can…Continue Reading

Clinical high-risk states describe assessed patterns associated with an increased probability of developing psychosis compared with some comparison groups. Criteria may include attenuated symptoms, brief psychotic experiences or certain combinations of vulnerability and functional decline.…Continue Reading

Anxiety, low mood, irritability or emotional withdrawal can appear before a first episode of psychosis. These changes are non-specific: they are also common in many other conditions and during stressful periods. Their presence cannot identify…Continue Reading

Unusual experiences before psychosis may include fleeting suspiciousness, changes in perception or a sense that ordinary events carry special significance. The person may remain uncertain about their meaning and able to consider alternatives. Clinicians sometimes…Continue Reading